Posts tagged: 2007

Shauna Paradine, ’08

Richardson, R. D., Page, T. K., Altermann, S., Paradine, S. M., French, A. N., & Wirth, T. (2007). Enantioselective Alpha-Oxytosylation of Ketones Catalysed by Iodoarenes. Synlett(4), 538-542.

Abstract: The alpha-oxytosylation of ketones catalysed by enantioenriched iodoarenes using mCPBA as stoichiometric oxidant is reported to give useful synthetic intermediates in good yield and modest enantioselectivity. We believe this to be the first report of an enantioselective catalytic reaction involving hypervalent iodine reagents which should open up a new field for enantioselective organocatalysis of oxidation reactions.

Stephanie Clark, Eric Grunow, Andrew Hasley, Brandon Hill, and Wendy Simanton

Duman-Scheel, M., Clark, S. M., Grunow, E. T., Hasley, A. O., Hill, B. L., & Simanton, W. L. (2007). Delayed Onset of Midline Netrin Expression in Artemia Franciscana Coincides with Commissural Axon Growth and Provides Evidence for Homology of Midline Cells in Distantly Related Arthropods. Evolution & Development, 9(2), 131-140.

Abstract: Although many similarities in arthropod central nervous systems (CNS) development exist, differences in midline cell formation and ventral nerve cord axonogenesis have been noted in arthropods. It is possible that changes in the expression of axon guidance molecules such as Netrin, which functions during commissural axon guidance in Drosophila and many other organisms, may parallel these differences. In this investigation, we analyze this hypothesis by examining Netrin accumulation during development of the brine shrimp Artemia franciscana, a branchiopod crustacean. An Artemia franciscana netrin (afrnet) orthologue was cloned. An antibody to the afrNet protein was generated and used to examine the pattern of afrNet accumulation during Artemia development. Despite differences between Drosophila and Artemia nerve cord development, examination of afrNet accumulation suggests that this protein functions to regulate commissure formation during Artemia CNS development. However, detection of afrNet at the midline and on commissural axons occurs at a relatively later time point in Artemia as compared with Drosophila. Detection of afrNet in a subset of midline cells that closely resemble Netrin-expressing cells at the Drosophila midline provides evidence for homology of midline cells in arthropods. Expression of Netrins in many other tissues is comparable, suggesting that Netrin proteins may play many conserved roles during arthropod development.

Emily Weber

Togunde, D., & Weber, E. (2007). Parents’ Views, Children’s Voices: Intergenerational Analysis of Child Labor Persistence in Urban Nigeria. International Journal of Sociology of the Family, 33(2), 285-301.

Abstract: This paper draws on interviews with 1535 parents and their children to provide a comprehensive analysis of the intergenerational dynamic of child labor persistence. From the perspectives of two generations, findings show that child labor is caused by poverty and the need to provide children with training for future careers. Furthermore, a significant number of parents had worked for their own parents while growing up, and this experience influenced their decision to ask their children to work. Moreover less than a third of the children plan to utilize the labor of their children when they become adults. Anxiety about financial future serves as a major reason for current child laborers to expect child labor to continue with the next generation. The remaining two-thirds who don’t plan to utilize child labor mentioned numerous hazards and dangers they counter as compelling reasons to end child labor. Interestingly, children of parents with higher socio-economic status are less likely to desire child labor continuation. Child labor practices may be quite resistant to change in a culture of poverty, however, because it carries tangible social and economic advantages in weak economies. Findings have policy implications for regulating child labor in Nigeria.

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